Development & Morphogenesis

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Tissue Tectonics

Using information about tissue scale deformations and cell level deformations, we derive a new quantitative definition of cell intercalation and use it to characterise tissue morphogenesis.

References:

G.B. Blanchard, A.J. Kabla, N.L. Schultz, L.C. Butler, B. Sanson, N. Gorfinkiel, L. Mahadevan and R.J. Adams,
Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation,
Nature Methods 6:458-464 (2009),
doi:10.1038/nmeth.1327

L.C. Butler, G.B. Blanchard, A.J. Kabla, N.J. Lawrence, D.P. Welchman, L. Mahadevan, R.J. Adams and B. Sanson,
Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension,
Nature Cell Biology 11(7):859-64 (2009),
doi:10.1038/ncb1894

A.J. Kabla, G.B. Blanchard, R.J. Adams and L. Mahadevan,
Bridging cell and tissue behaviour in embryomorphogenesis,
Book chapter in Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling, Taylor and Francis ed., pages 351-377 (2010),
doi:ISBN 9781420094541

D. Bhattacharya, J. Zhong, S. Tavakoli, A. Kabla and P. Matsudaira,
Strain maps characterize the symmetry of convergence and extension patterns during zebrafish gastrulation,
Scientific Reports volume 11:19357 (2021),
doi:10.1038/s41598-021-98233-z