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Alexandre Kabla
Mechanobiology and Soft Matter Group

Work space

  • Suspended monolayers. How do we hold, stretch and measure a free-standing epithelium, and what does its mechanical response say about the cells?
  • Epithelial bending and folding. How do tension, compression and curvature make epithelial sheets curl, buckle or stay flat?
  • Junctions, division, packing. How do junction tension and fluctuations set cell packing and the orientation of cell division?
  • Tissue integrity. How do epithelial tissues keep their barrier intact, and what makes them rupture, heal or fail under repeated stretch?
  • Cell adhesion. How do cells hold on to their matrix and to each other, and what does adhesion tell us about cells and tissues?
  • Cell mechanics in confinement. How do single cells, and their nuclei, respond to compression and confinement?
  • Tissue tectonics. How do cell rearrangements and shape changes add up to tissue deformation in the embryo?
  • Patterning and sorting. How do simple local rules make cells organise in space, from leaders and followers to sorted cell types and emerging patterns?
  • Collective migration guidance. How do geometry and substrate cues steer groups of migrating cells?
  • Leadership and invasion. What decides who leads a migrating group, and how do heterogeneous groups invade?
  • Foam rheology. How do 2D foams respond to slow shear, from small deformations to shear banding?
  • Granular matter. How do contacts, forces and density evolve in slowly deformed grain packs?
  • Soft fibre networks. How do disordered fibre networks stiffen, align and carry load?
  • Viscoelastic models and RHEOS. How do we describe the power-law relaxation of complex fluids, cells and tissues, and build open tools to quantify it?
  • Microbial calcite (MICP). Can bacteria strengthen soil from within, and how should the treatment be designed?
  • Acoustofluidics. How do acoustic waves in microchannels move and concentrate particles and cells?
  • Instruments and imaging. Which instruments and imaging methods make measurement cheaper, open and clinically useful?
  • Glioblastoma heterogeneity. How do glioblastoma cells at the tumour margin differ from those in the core, and why does this heterogeneity matter for invasion and for testing treatments?
  • Open technology for equity. How can designs, courses and student projects be shared so they work where resources are scarce?
  • Vesicle proto-tissues. How do adhesive vesicle suspensions behave as model tissues?